Healthcare Economic Information (HCEI) Studies

EXPAREL has demonstrated clinical and economic value across various real-world studies in both inpatient and outpatient settings.

Click on a study below to see how EXPAREL performed

For additional scientific information regarding EXPAREL, please visit medinfo.pacira.com or call (855) 793-9727.

Inpatient

EXPAREL vs bupivacaine in TKA
See the inpatient TKA study
Investigator-initiated
EXPAREL vs ropivacaine CISNB catheter in TSA
See the inpatient TSA study
Investigator-initiated
EXPAREL vs non-EXPAREL in hip fracture surgeries
See the hip fracture study
Investigator-initiated
EXPAREL vs non-EXPAREL in lumbar spinal fusion
See the spinal fusion study
Investigator-initiated

Outpatient

EXPAREL vs non-EXPAREL in TKA ASC surgeries
Explore our approach
EXPAREL vs non-EXPAREL for TSA
See the outpatient TSA study

Additional Studies

Procedure Article
Total Knee Arthroplasty (TKA)

Liposomal bupivacaine versus continuous nerve block: liposomal bupivacaine may be non-inferior and more cost effective

Lonza G, et al. 2023

Adductor canal block vs liposomal bupivacaine periarticular injection in total knee arthroplasty: a randomized controlled trial

Than J, et al. 2021
Total Shoulder Arthroplasty (TSA)

A retrospective comparison of interscalene continuous catheter verse single-injection with liposomal bupivacaine in total shoulder arthroplasty

Kenny B, et al. 2021

Single-shot liposomal bupivacaine interscalene nerve block provides equivalent pain relief compared to continuous catheter interscalene nerve block in total shoulder arthroplasty

Budge M, et al. 2020
Hip Fracture

Liposomal bupivacaine associated with cost savings during postoperative pain management in fragility intertrochanteric hip fractures

Chintalapudi N, et al. 2022
Total Hip Arthroplasty (THA)

Local infiltration for postsurgical analgesia following total hip arthroplasty: a comparison of liposomal bupivacaine to traditional bupivacaine

Asche C, et al. 2017
Lumbar Spinal Fusion

Intramuscular liposomal bupivacaine decreases length of stay and opioid usage following lumbar spinal fusion

Roh MS, et al. 2020
Colorectal

Real-world data on liposomal bupivacaine and inpatient hospital costs after colorectal surgery

Tran J, et al. 2022
Abdominal

Economic outcomes and incidence of postsurgical hypotension with liposomal bupivacaine vs epidural analgesia in abdominal surgeries

Holtz M, et al. 2022

A cost-minimization analysis evaluating the use of liposomal bupivacaine in reconstructive plastic surgery procedures

Little A, et al. 2019
Cardiothoracic Pediatrics

Effectiveness of liposomal bupivacaine compared with standard-of-care measures in pediatric cardiothoracic surgery: a retrospective cohort study

Tirotta C, et al. 2021
Procedure Article
Total Knee Arthroplasty (TKA)

Real-world impact of treatment with liposomal bupivacaine on health care resource utilization, opioid consumption, and cost among patients undergoing total knee arthroplasty in ambulatory surgical settings in the United States

Lin J, et al. 2025
Total Shoulder Arthroplasty (TSA)

Randomized clinical trial comparing mixed liposomal bupivacaine vs. continuous catheter for interscalene block during shoulder arthroplasty: a comparison of analgesia, patient experience, and cost

Panchamia J, et al. 2025

Clinical and health economic outcomes with and without liposomal bupivacaine in Medicare-insured patients undergoing outpatient shoulder arthroplasty

Abboud J, et al. 2025

Liposomal bupivacaine nerve block provides better pain control post-total shoulder arthroplasty than continuous indwelling catheter

Krupp R, et al. 2023
Important Safety Information

Indication

EXPAREL® (bupivacaine liposome injectable suspension) is indicated to produce postsurgical local analgesia via infiltration in patients aged 6 years and older and regional analgesia in adults via an interscalene brachial plexus nerve block, sciatic nerve block in the popliteal fossa, and an adductor canal block.

Important Safety Information

  • EXPAREL is contraindicated in obstetrical paracervical block anesthesia
  • Adverse reactions reported in adults with an incidence greater than or equal to 10% following EXPAREL administration via infiltration were nausea, constipation, and vomiting; adverse reactions reported in adults with an incidence greater than or equal to 10% following EXPAREL administration via nerve block were nausea, pyrexia, headache, and constipation
  • Adverse reactions with an incidence greater than or equal to 10% following EXPAREL administration via infiltration in pediatric patients six to less than 17 years of age were nausea, vomiting, constipation, hypotension, anemia, muscle twitching, vision blurred, pruritus, and tachycardia
Important Safety Information
Important Safety Information

Indication

EXPAREL® (bupivacaine liposome injectable suspension) is indicated to produce postsurgical local analgesia via infiltration in patients aged 6 years and older and regional analgesia in adults via an interscalene brachial plexus nerve block, sciatic nerve block in the popliteal fossa, and an adductor canal block. Safety and efficacy have not been established in other nerve blocks.

Important Safety Information

  • EXPAREL is contraindicated in obstetrical paracervical block anesthesia
  • Adverse reactions reported in adults with an incidence greater than or equal to 10% following EXPAREL administration via infiltration were nausea, constipation, and vomiting; adverse reactions reported in adults with an incidence greater than or equal to 10% following EXPAREL administration via nerve block were nausea, pyrexia, headache, and constipation
  • Adverse reactions with an incidence greater than or equal to 10% following EXPAREL administration via infiltration in pediatric patients six to less than 17 years of age were nausea, vomiting, constipation, hypotension, anemia, muscle twitching, vision blurred, pruritus, and tachycardia
  • Do not admix lidocaine or other non-bupivacaine local anesthetics with EXPAREL. EXPAREL may be administered at least 20 minutes or more following local administration of lidocaine
  • EXPAREL is not recommended to be used in the following patient populations: patients <6 years old for infiltration, patients younger than 18 years old for nerve blocks, and/or pregnant patients
  • Because amide-type local anesthetics, such as bupivacaine, are metabolized by the liver, EXPAREL should be used cautiously in patients with hepatic disease

Warnings and Precautions Specific to EXPAREL

  • Avoid additional use of local anesthetics within 96 hours following administration of EXPAREL
  • EXPAREL is not recommended for the following types or routes of administration: epidural, intrathecal, regional nerve blocks other than interscalene brachial plexus nerve block, sciatic nerve block in the popliteal fossa, and adductor canal block, or intravascular or intra-articular use
  • The potential sensory and/or motor loss with EXPAREL is temporary and varies in degree and duration depending on the site of injection and dosage administered and may last for up to 5 days, as seen in clinical trials

Warnings and Precautions for Bupivacaine-Containing Products

  • Central Nervous System (CNS) Reactions: There have been reports of adverse neurologic reactions with the use of local anesthetics. These include persistent anesthesia and paresthesia. CNS reactions are characterized by excitation and/or depression
  • Cardiovascular System Reactions: Toxic blood concentrations depress cardiac conductivity and excitability, which may lead to dysrhythmias, sometimes leading to death
  • Allergic Reactions: Allergic-type reactions (eg, anaphylaxis and angioedema) are rare and may occur as a result of hypersensitivity to the local anesthetic or to other formulation ingredients
  • Chondrolysis: There have been reports of chondrolysis (mostly in the shoulder joint) following intra-articular infusion of local anesthetics, which is an unapproved use
  • Methemoglobinemia: Cases of methemoglobinemia have been reported with local anesthetic use

Please refer to full Prescribing Information.